Understanding how fungi control gene expression
Official title: Translational control of gene expression in fungi
Funded at Texas A&m University · NIH-10891656 · Data updated 2026-11-12
This study is looking at how fungi control the production of important proteins that help them grow and respond to their surroundings, which could help us better understand and treat fungal infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $301,037 |
| NIH project number | 5R01GM148702-02 |
| Project ID | NIH-10891656 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with fungal infections or those at risk of developing such infections.
✕Less likely to help
Patients with non-fungal related health issues may not receive any benefit from this research.
What this research studies
This research investigates the mechanisms by which fungi regulate gene expression through a process called translation. It focuses on specific segments of mRNA known as upstream open reading frames (uORFs), which play critical roles in controlling the production of proteins essential for fungal metabolism. By studying a newly discovered peptide that regulates these processes, the research aims to fill gaps in knowledge about how fungi respond to their environment and manage their growth. This could lead to insights into how fungal infections are managed and treated.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating fungal infections that affect human health.
How similar studies have gone: Other research has shown promising results in understanding gene regulation in fungi, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Texas A&m University
College Station, United States Active
Researchers
- Principal investigator: Sachs, Matthew Steven — Texas A&m University
- Study coordinator: Sachs, Matthew Steven
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.