Understanding how fungi can become harmful to humans
The Evolution and Genetics of Fungal Virulence
['FUNDING_R15'] · COLLEGE OF WILLIAM AND MARY · NIH-10796489
This study looks at how some fungi that usually live in nature can change in ways that make them dangerous to people, and by understanding these changes, researchers hope to find better ways to prevent and treat fungal infections.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLLEGE OF WILLIAM AND MARY (nih funded) |
| Locations | 1 site (WILLIAMSBURG, UNITED STATES) |
| Trial ID | NIH-10796489 on ClinicalTrials.gov |
What this research studies
This research investigates how certain fungi, which typically thrive in the environment, can develop traits that make them harmful to humans. The approach focuses on understanding the genetic adaptations that allow these fungi to survive and potentially cause disease when they encounter human hosts. By studying the evolutionary history and genetic makeup of these fungi, researchers aim to uncover the mechanisms behind their virulence. This knowledge could help in developing strategies to prevent and treat fungal infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of fungal infections, particularly those with weakened immune systems or underlying health conditions.
Not a fit: Patients who are not at risk for fungal infections or who have no history of such infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment options for fungal infections, which are increasingly recognized as significant health threats.
How similar studies have performed: Other research has shown success in understanding the genetic basis of pathogenicity in various microbes, suggesting that this approach could yield valuable insights into fungal virulence as well.
Where this research is happening
WILLIAMSBURG, UNITED STATES
- COLLEGE OF WILLIAM AND MARY — WILLIAMSBURG, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MURPHY, HELEN ANNE — COLLEGE OF WILLIAM AND MARY
- Study coordinator: MURPHY, HELEN ANNE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.