Understanding how fungi and bacteria interact during infections
Official title: Defining mechanisms of fungal-bacterial interactions during infection
Funded at Clemson University · NIH-11051797 · Data updated 2026-11-12
This study is looking at how two germs, Aspergillus fumigatus and Pseudomonas aeruginosa, work together during infections in people with cystic fibrosis, to help us understand how they affect each other and change in patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Clemson University NIH-funded |
| Lab location | 1 site (Clemson, United States) |
| Project start | March 7, 2024 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $100,000 |
| NIH project number | 5K22AI174009-02 |
| Project ID | NIH-11051797 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cystic fibrosis who are experiencing infections caused by Aspergillus fumigatus and Pseudomonas aeruginosa.
✕Less likely to help
Patients without cystic fibrosis or those not infected with Aspergillus fumigatus or Pseudomonas aeruginosa may not benefit from this research.
What this research studies
This research investigates the interactions between the fungal pathogen Aspergillus fumigatus and the bacterial pathogen Pseudomonas aeruginosa, particularly in the context of cystic fibrosis (CF) infections. By using advanced techniques such as multi-omics approaches and reverse genetics, the study aims to uncover how these two organisms communicate and affect each other's physiology during infection. The research will also explore whether these interactions change in clinical isolates from CF patients, providing insights into the dynamics of polymicrobial infections.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with cystic fibrosis who are suffering from complex infections.
How similar studies have gone: Previous research has shown promising results in understanding microbial interactions in infections, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Clemson University
Clemson, United States Active
Researchers
- Principal investigator: Dolan, Stephen K — Clemson University
- Study coordinator: Dolan, Stephen K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.