Understanding how Frizzled receptors affect the development of the palate
Deciphering the Role of Frizzled Receptors in Palatal Development
This study is looking into how certain genes and signals in the body affect the development of the roof of the mouth, especially for people with cleft lip and palate, to find new ways to help improve treatments for these conditions.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Van Andel Research Institute NIH-funded |
| Lab location | 1 site (Grand Rapids, United States) |
| Project ID | NIH-10899527 on NIH RePORTER |
What this research studies
This research investigates the genetic and signaling mechanisms involved in the development of the palate, particularly focusing on Frizzled receptors and their role in cleft lip and palate conditions. By studying the Wnt signaling pathway and its interactions with other pathways, the research aims to uncover how these factors contribute to proper palatal development. The goal is to identify potential targets for therapies that could improve treatment outcomes for patients with orofacial clefts. This work involves advanced techniques such as CRISPR to analyze genetic mutations associated with these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include infants diagnosed with cleft lip and/or cleft palate, as well as families with a history of these conditions.
Not a fit: Patients with cleft conditions not associated with genetic mutations in Frizzled receptors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive strategies for cleft lip and palate, ultimately enhancing patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding the genetic factors involved in cleft conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
Grand Rapids, United States
- Van Andel Research Institute — Grand Rapids, United States (Active)
Researchers
- Principal investigator: Michalski, Megan — Van Andel Research Institute
- Study coordinator: Michalski, Megan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.