Understanding how Francisella tularensis affects host cell responses
Modulation of Host Cell Responses by Francisella tularensis
This study looks at how the bacteria that cause tularemia, called Francisella tularensis, manages to hide from our immune system, focusing on a special protein named TolC that helps it survive and grow inside our cells, with the goal of finding new ways to understand and fight this infection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-10623247 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the bacterium Francisella tularensis, responsible for the disease tularemia, evades the immune response of host cells. The study focuses on a specific protein called TolC, which plays a crucial role in the bacterium's ability to survive and replicate within host cells. By examining how TolC suppresses immune responses, the research aims to uncover new insights into the virulence of this pathogen and its interactions with the host's immune system.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who may be at risk of tularemia or have been exposed to Francisella tularensis.
Not a fit: Patients who are not at risk of tularemia or have no history of exposure to this bacterium may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating infections caused by Francisella tularensis.
How similar studies have performed: Other research has shown success in understanding bacterial pathogenesis through similar mechanisms, indicating that this approach has potential for yielding valuable insights.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Thanassi, David G — State University New York Stony Brook
- Study coordinator: Thanassi, David G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.