Understanding how frailty affects osteoporosis and fractures in veterans with rheumatoid arthritis

Who could benefit from this research

What this research studies

This research investigates the relationship between frailty, osteoporosis, and fractures specifically in veterans suffering from rheumatoid arthritis (RA). It aims to understand how chronic inflammation, a hallmark of RA, contributes to both frailty and decreased bone mineral density. By studying inflammatory biomarkers and their impact on these conditions, the research seeks to identify potential interventions that could improve patient outcomes. The study focuses on veterans, who are at a higher risk for these complications, to develop tailored management strategies.

Why it matters

Where this research is happening

• VA Puget Sound Healthcare System
  Seattle, United States Active

Researchers

• Principal investigator: Wysham, Katherine D — VA Puget Sound Healthcare System
• Study coordinator: Wysham, Katherine D

Related research

Other NIH-funded projects on the same topics.

• How frailty affects bone loss and broken bones in Veterans with rheumatoid arthritis

  This project looks at how being frail changes bone strength and the chance of broken bones in Veterans who have rheumatoid arthritis.

  NIH research VA Puget Sound Healthcare System · Seattle, United States · NIH-11132666

• Gut microbes and methotrexate: boosting RA treatment through microbiome targets

  Researchers are studying how gut bacteria affect how well methotrexate works for people with rheumatoid arthritis, aiming to make MTX effective for more patients.

  NIH research Veterans Affairs Med Ctr San Francisco · San Francisco, United States · NIH-11606746

• Hybrid biomaterial system to boost immunotherapy for rheumatoid arthritis

  A new, patient-facing immunotherapy approach uses specialized particles to retrain the immune system to calm RA in adults.

  NIH research University of Florida · Gainesville, United States · NIH-11552872

• Role of Stabilin receptors in rheumatoid arthritis

  A short study to understand how certain scavenger receptors may influence the development and progression of rheumatoid arthritis in adults.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11453262

• IgG glycosylation and endothelial FcγRIIB: understanding RA-related heart and blood vessel disease

  This project looks at how rheumatoid arthritis affects blood vessels and clotting, with the goal of uncovering new ways to prevent heart and stroke risk for people with RA.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11448488

• Risk factors and biomarkers for progression of subclinical RA-related lung disease

  This study follows people with rheumatoid arthritis to understand who develops lung disease and what biomarkers predict it.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11447980

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.