Understanding how fragmented chromosomes contribute to cancer development
Genomic Instability from Fragmented Chromosomes in Micronuclei
['FUNDING_OTHER'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11090494
This study is looking at how certain mistakes during cell division can cause chromosomes to break apart, which might lead to cancer, and it's designed for anyone interested in understanding how these changes happen and what they mean for health.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11090494 on ClinicalTrials.gov |
What this research studies
This research investigates the phenomenon of chromothripsis, where chromosomes become fragmented during cell division errors, leading to cancerous changes. By creating a controlled environment to study these fragmented chromosomes, researchers aim to understand how these abnormalities arise and contribute to genomic instability. The study focuses on monitoring micronuclei, which are abnormal structures that encapsulate mis-segregated chromosomes, to uncover the mechanisms behind chromosomal rearrangements. This could provide insights into the processes that lead to various cancers and genetic disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with cancers characterized by chromosomal instability or those with genetic disorders linked to chromosomal abnormalities.
Not a fit: Patients with stable genomes or those without chromosomal abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers associated with chromosomal abnormalities.
How similar studies have performed: Previous research has shown promising results in understanding chromosomal abnormalities, but the specific approach of studying chromothripsis in this manner is relatively novel.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LY, PETER — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: LY, PETER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: cancer cell genome, cancer genome, Cancers