Understanding how fragile sites in chromosomes lead to DNA damage
Official title: Mechanisms of Chromosome Fragile Site Formation in the Human Genome
Funded at Upstate Medical University · NIH-10811039 · Data updated 2026-11-12
This study is looking at specific spots in our DNA that can easily get damaged, which might lead to serious health problems like cancer or neurological disorders, and it's for anyone interested in understanding how these DNA issues happen and what they mean for our health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project start | September 24, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $448,250 |
| NIH project number | 1R21HG012629-01A1 |
| Project ID | NIH-10811039 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a family history of cancer or genetic disorders linked to DNA instability.
✕Less likely to help
Patients with no known genetic predispositions or those not affected by conditions related to DNA damage may not benefit from this research.
What this research studies
This research investigates common fragile sites (CFSs) in the human genome, which are areas prone to DNA damage and can lead to serious health issues like cancer and neurological disorders. The researchers will use advanced sequencing techniques to map DNA breaks and gaps in these fragile sites, aiming to understand the mechanisms behind their formation and the impact of replication stress. By comparing different technological approaches, they hope to clarify how these fragile sites contribute to genetic instability. This work could provide insights into the underlying causes of various diseases linked to DNA damage.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for diseases associated with DNA damage, such as cancer.
How similar studies have gone: Previous research has shown that understanding DNA damage mechanisms can lead to significant advancements in cancer treatment, indicating that this approach has potential for success.
Where this research is happening
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Upstate Medical University
Syracuse, United States Active
Researchers
- Principal investigator: Feng, Wenyi — Upstate Medical University
- Study coordinator: Feng, Wenyi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.