Understanding how FOXR2 and ETS factors work together in childhood brain tumors
Dissecting the cooperation of FOXR2 and ETS transcription factors in FOXR2-expressing diffuse midline gliomas
This study is looking at how a protein called FOXR2 affects the growth of aggressive brain tumors in children, with the hope that understanding this could lead to better treatments for patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hospital of Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10807829 on NIH RePORTER |
What this research studies
This research investigates the role of FOXR2, a transcription factor, in the development of diffuse midline gliomas (DMGs), which are aggressive brain tumors in children. The study aims to understand how FOXR2 interacts with other transcription factors, specifically ETS factors, to promote tumor growth and activate signaling pathways like MAPK. By using advanced techniques, including CRISPR, the research will explore the molecular mechanisms behind these tumors, potentially leading to new therapeutic strategies. Patients may benefit from insights gained into the biology of their tumors, which could inform future treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with diffuse midline gliomas, particularly those with FOXR2 expression.
Not a fit: Patients with other types of brain tumors that do not involve FOXR2 or ETS transcription factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for children suffering from diffuse midline gliomas.
How similar studies have performed: While the specific approach of targeting FOXR2 and ETS factors in DMGs is novel, similar research has shown promise in understanding other tumor types through transcription factor interactions.
Where this research is happening
Los Angeles, United States
- Children's Hospital of Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Tsai, Jessica Whei — Children's Hospital of Los Angeles
- Study coordinator: Tsai, Jessica Whei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.