Understanding how FOXP1 affects brain development and function
Official title: Identifying the downstream targets of neural FOXP1
Funded at Weill Medical Coll of Cornell Univ · NIH-11011920 · Data updated 2026-11-12
This study is looking at how a gene called FOXP1 affects brain cells in people with FOXP1 syndrome, a condition that can lead to difficulties with language and autism, to better understand how it works and find new ways to help those affected.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | December 9, 2024 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $169,500 |
| NIH project number | 1R03MH133952-01A1 |
| Project ID | NIH-11011920 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with FOXP1 syndrome or those exhibiting similar neurodevelopmental challenges, particularly under the age of 21.
✕Less likely to help
Patients without any neurodevelopmental disorders or those not affected by FOXP1 syndrome may not benefit from this research.
What this research studies
This research investigates the role of FOXP1, a gene linked to a rare neurodevelopmental disorder known as FOXP1 syndrome, which can cause significant challenges such as language impairment and autism symptoms. The study aims to identify the specific targets that FOXP1 interacts with in neural cells, particularly focusing on human cortical neural progenitor cells and neurons. By analyzing these interactions, the research seeks to uncover the transcriptional networks regulated by FOXP1, which could provide insights into the mechanisms of the disorder and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for individuals affected by FOXP1 syndrome and related neurodevelopmental disorders.
How similar studies have gone: While the specific focus on FOXP1 in this context may be novel, there have been successful studies exploring the roles of similar transcription factors in neurodevelopmental disorders.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Pearson, Caroline Alayne — Weill Medical Coll of Cornell Univ
- Study coordinator: Pearson, Caroline Alayne
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.