Understanding how FOXO factors influence stem cell behavior and related pathways
Investigating fundamental signal transduction mechanisms impacted by FOXO transcription factors on NOTCH and JAK/STAT Pathways in stem cell contexts
This study is looking at how certain proteins called FOXO help stem cells stay healthy and avoid turning into other types of cells, which could help us learn more about how stem cells work and how diseases like cancer develop.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Rio Grande Valley NIH-funded |
| Lab location | 1 site (Edinburg, United States) |
| Project ID | NIH-10850085 on NIH RePORTER |
What this research studies
This research investigates the role of FOXO transcription factors in stem cells, focusing on how they interact with important signaling pathways like NOTCH and JAK/STAT. By examining these interactions, the research aims to uncover the mechanisms that allow stem cells to maintain their properties and resist differentiation. The study employs advanced techniques such as ATAC sequencing to analyze gene expression and regulatory elements in stem cells. This could lead to a better understanding of both normal stem cell function and the development of diseases like cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to stem cell dysfunction or cancer, particularly those involving the NOTCH and JAK/STAT pathways.
Not a fit: Patients with conditions unrelated to stem cell biology or the specific pathways being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing stem cell therapies and improving treatments for cancer.
How similar studies have performed: Previous research has shown promising results in understanding the roles of FOXO factors in stem cells, indicating that this approach has potential for significant findings.
Where this research is happening
Edinburg, United States
- University of Texas Rio Grande Valley — Edinburg, United States (Active)
Researchers
- Principal investigator: Keniry, Megan E — University of Texas Rio Grande Valley
- Study coordinator: Keniry, Megan E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.