Understanding how FOSL1 affects prostate cancer's response to treatment
Official title: Dissecting FOSL1-mediated lineage plasticity and resistance to androgen receptor signaling inhibition in prostate cancer
Funded at Sloan-Kettering Inst Can Research · NIH-11035198 · Data updated 2026-11-12
This study is looking at how a specific gene called FOSL1 affects prostate cancer, especially why some cancers keep growing even when treated, and it hopes to find new ways to make treatments work better for patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $173,016 |
| NIH project number | 5K99CA286721-02 |
| Project ID | NIH-11035198 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with castration-resistant prostate cancer who have experienced treatment failure with androgen receptor signaling inhibitors.
✕Less likely to help
Patients with early-stage prostate cancer or those who have not undergone androgen deprivation therapy may not benefit from this research.
What this research studies
This research investigates the role of the FOSL1 gene in prostate cancer, particularly how it contributes to the cancer's ability to resist treatments that target androgen receptors. By using patient-derived organoid models, the study aims to identify different subtypes of castration-resistant prostate cancer and understand the mechanisms that allow these cancers to grow despite therapy. The research will also explore potential therapeutic vulnerabilities that could be targeted to improve treatment outcomes for patients.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment strategies for patients with advanced prostate cancer that is resistant to current therapies.
How similar studies have gone: Previous research has shown promising results in targeting genetic factors involved in cancer resistance, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Wong, Chen Khuan — Sloan-Kettering Inst Can Research
- Study coordinator: Wong, Chen Khuan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.