Understanding how FOSL1 affects prostate cancer's response to treatment
Dissecting FOSL1-mediated lineage plasticity and resistance to androgen receptor signaling inhibition in prostate cancer
This study is looking at how a specific gene called FOSL1 affects prostate cancer, especially why some cancers keep growing even when treated, and it hopes to find new ways to make treatments work better for patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11035198 on NIH RePORTER |
What this research studies
This research investigates the role of the FOSL1 gene in prostate cancer, particularly how it contributes to the cancer's ability to resist treatments that target androgen receptors. By using patient-derived organoid models, the study aims to identify different subtypes of castration-resistant prostate cancer and understand the mechanisms that allow these cancers to grow despite therapy. The research will also explore potential therapeutic vulnerabilities that could be targeted to improve treatment outcomes for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with castration-resistant prostate cancer who have experienced treatment failure with androgen receptor signaling inhibitors.
Not a fit: Patients with early-stage prostate cancer or those who have not undergone androgen deprivation therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment strategies for patients with advanced prostate cancer that is resistant to current therapies.
How similar studies have performed: Previous research has shown promising results in targeting genetic factors involved in cancer resistance, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Wong, Chen Khuan — Sloan-Kettering Inst Can Research
- Study coordinator: Wong, Chen Khuan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.