Understanding how Fork Head proteins regulate organ development and metabolism
Official title: Uncovering the Regulatory Mechanisms of the Fork Head Transcription Factor
Funded at Johns Hopkins University · NIH-10996811 · Data updated 2026-11-12
This study is looking at how certain proteins help shape organs and manage metabolism, using fruit flies to learn more about their role, which could help us understand some cancers and metabolic issues better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $49,774 |
| NIH project number | 1F31DE034305-01 |
| Project ID | NIH-10996811 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers or metabolic disorders linked to Fork Head protein mutations.
✕Less likely to help
Patients without any known genetic mutations in Fork Head proteins or those with unrelated conditions may not benefit from this research.
What this research studies
This research investigates the role of Fork Head transcription factors in organ development and metabolic regulation. By studying the Drosophila model, the project aims to uncover how these proteins interact with other transcription factors to influence organ formation and function. The methodology includes advanced techniques like ChIP-sequencing and single-cell RNA sequencing to analyze gene expression and protein interactions. This research could provide insights into the mechanisms behind certain cancers and metabolic disorders linked to mutations in these proteins.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for cancers and metabolic disorders associated with Fork Head protein mutations.
How similar studies have gone: Previous research has shown success in understanding transcription factors in other contexts, suggesting potential for breakthroughs in this area.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Laughner, Nathaniel — Johns Hopkins University
- Study coordinator: Laughner, Nathaniel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.