Understanding how food allergens trigger reactions in the gut
Pro-Type 2 Goblet Cell Antigen Passages in Food Sensitization and Reactivity
This work explores how certain cells in the gut process food particles, which could help us find new ways to prevent or treat food allergies.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11122245 on NIH RePORTER |
What this research studies
Our team is looking into how special cells in the gut, called goblet cells, handle food particles. We've found that in people with food allergies, these cells might process food differently, leading to allergic reactions. This project aims to understand these differences better, especially how certain immune signals contribute to these reactions. By uncovering these mechanisms, we hope to pave the way for new and safer treatments for food allergies.
Who could benefit from this research
Good fit: This foundational research is relevant to individuals, especially children, who experience food allergies.
Not a fit: Patients without food allergies would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that prevent or reduce severe allergic reactions to food.
How similar studies have performed: Previous work by this team has identified key pathways in how the gut processes food antigens, showing promise for this line of investigation.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Hogan, Simon Patrick — University of Michigan at Ann Arbor
- Study coordinator: Hogan, Simon Patrick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.