Understanding how fmnl2 affects brain development
Investigation of fmnl2 in cerebellar development
This study is looking at how a specific gene affects the development of the part of the brain that helps with movement and coordination, to better understand how problems in this process can lead to coordination disorders, and it's designed for anyone interested in the genetic causes of these conditions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11093490 on NIH RePORTER |
What this research studies
This research investigates the role of the fmnl2 gene in the development of the cerebellum, a part of the brain that controls movement and coordination. It focuses on how disruptions in signaling pathways during brain development can lead to congenital ataxias, which are disorders characterized by impaired coordination. By studying mouse models with similar symptoms, researchers aim to uncover the genetic and cellular mechanisms that contribute to these conditions. The approach includes genetic screening and analysis of cellular structures involved in brain development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital ataxias or related cerebellar disorders, particularly those with genetic backgrounds that may involve ciliary dysfunction.
Not a fit: Patients with ataxia not linked to genetic or developmental abnormalities in the cerebellum may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the causes of congenital ataxias and potential therapeutic targets for treatment.
How similar studies have performed: Previous research has shown success in understanding genetic contributions to cerebellar disorders, but the specific role of fmnl2 in this context is still being explored.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Tran, Joyce — University of California, San Diego
- Study coordinator: Tran, Joyce
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.