Understanding how fluid movement affects cells and tissues
Integrative Approaches for the Study of the Fluidic Cellular Microenvironment
This study is exploring how the movement of fluids around cells affects their behavior and how they work together in tissues, which could help us understand important processes like development and healing.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10895502 on NIH RePORTER |
What this research studies
This research investigates the role of fluid as a crucial part of the cellular environment and how its movement influences cell and tissue behavior. By using advanced techniques like microfabrication and microfluidic devices, the research aims to uncover how cells detect and respond to fluid flow. The study focuses on the forces exerted by moving fluids on cells, the molecular mechanisms that translate these forces into biological actions, and how these responses are coordinated at the tissue level. The research is particularly interested in areas where the effects of fluid transport are not well understood, such as during development and tissue formation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by cancers or cardiovascular diseases, as well as those interested in developmental biology.
Not a fit: Patients with conditions unrelated to cellular fluid dynamics or those not affected by the target diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into how fluid dynamics affect various diseases, potentially improving treatments for conditions like cancer and cardiovascular diseases.
How similar studies have performed: While the specific focus on fluid dynamics in cellular environments is relatively novel, related research has shown promising results in understanding cell behavior in response to mechanical forces.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Polacheck, William J — Univ of North Carolina Chapel Hill
- Study coordinator: Polacheck, William J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.