Understanding how fluid in the brain helps it grow and function
How cerebrospinal fluid (CSF) potassium supports brain development and activity
['FUNDING_R01'] · STANFORD UNIVERSITY · NIH-11173888
This project explores how the fluid surrounding our brain and spinal cord, called cerebrospinal fluid (CSF), uses potassium to support healthy brain development and activity.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11173888 on ClinicalTrials.gov |
What this research studies
Our brains and spinal cords are bathed in cerebrospinal fluid (CSF), which is crucial for brain health, providing balance and growth factors. We've found that the amount of potassium in this fluid changes significantly as the brain develops, which could affect how brain cells grow and function. This work aims to understand how these potassium changes influence brain development, especially since imbalances in CSF are linked to various brain conditions and injuries. By controlling potassium levels in the CSF, we can learn more about its role in generating and maturing brain cells. This knowledge could help us understand and address problems related to brain development.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals affected by congenital, neuropsychiatric, infectious, or geriatric brain diseases, as well as those with brain injuries.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not receive benefit from participating in this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of how brain development occurs and how imbalances in brain fluid contribute to neurological conditions, potentially guiding future treatments.
How similar studies have performed: While the specific developmental changes in CSF potassium are a recent discovery, the general importance of CSF composition in brain health is well-established.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FAME, RYAN MARIE — STANFORD UNIVERSITY
- Study coordinator: FAME, RYAN MARIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.