Understanding how fluid forces influence lymphatic valve formation
Role of Piezo1-controlled Prox1 Modification in Lymphatic Valve Formation
['FUNDING_R01'] · UNIVERSITY OF SOUTHERN CALIFORNIA · NIH-11107218
This study is looking at how certain cells in your lymphatic system respond to the movement of fluid, which helps them create important structures called lymphatic valves, and it aims to find new ways to help people with lymphatic problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTHERN CALIFORNIA (nih funded) |
| Locations | 1 site (Los Angeles, UNITED STATES) |
| Trial ID | NIH-11107218 on ClinicalTrials.gov |
What this research studies
This research investigates how lymphatic endothelial cells sense fluid forces and convert these signals into biological processes that lead to the formation of lymphatic valves. The focus is on Piezo1, a mechanosensitive ion channel, which detects fluid flow and activates Prox1, a key transcription factor involved in lymphatic development. By using various methods, including laboratory experiments and animal models, the research aims to uncover the molecular mechanisms behind lymphatic valve formation and identify potential therapeutic targets for lymphatic disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting the lymphatic system or those at risk for lymphatic disorders.
Not a fit: Patients with non-lymphatic related conditions or those without any lymphatic system involvement may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for lymphatic-related disorders, improving patient outcomes.
How similar studies have performed: Previous research has shown promise in understanding mechanotransduction in other biological systems, suggesting potential success for this novel approach.
Where this research is happening
Los Angeles, UNITED STATES
- UNIVERSITY OF SOUTHERN CALIFORNIA — Los Angeles, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHOI, DONGWON — UNIVERSITY OF SOUTHERN CALIFORNIA
- Study coordinator: CHOI, DONGWON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.