Understanding how fluid flow affects heart and body development in zebrafish
Genetic dissection of fluid flow signaling in Left-Right patterning of zebrafish
This study is looking at how tiny fish embryos feel and react to the movement of fluids, which is important for their growth, and it aims to find new proteins that help with this process, potentially leading to better understanding of heart problems and other developmental issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oregon NIH-funded |
| Lab location | 1 site (Eugene, United States) |
| Project ID | NIH-10895470 on NIH RePORTER |
What this research studies
This research investigates how cells in zebrafish embryos sense and respond to fluid flow, which is crucial for proper development. By studying the left-right patterning system, the researchers aim to identify new proteins that help regulate this flow sensation and its effects on gene expression. The project involves advanced genetic techniques to explore the role of these proteins in forming cilia and generating fluid flow, which are essential for normal heart and body development. Insights gained from this research could help understand congenital heart defects and other developmental disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital heart defects or related developmental disorders.
Not a fit: Patients with conditions unrelated to fluid flow signaling or congenital heart defects may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating congenital heart defects and related developmental diseases.
How similar studies have performed: While the specific approach of this research is novel, previous studies have shown success in understanding fluid flow signaling in developmental biology.
Where this research is happening
Eugene, United States
- University of Oregon — Eugene, United States (Active)
Researchers
- Principal investigator: Fisher, Katherine H — University of Oregon
- Study coordinator: Fisher, Katherine H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.