Understanding how FLT3 mutations affect acute myeloid leukemia
Interrogating oncogene-dependency and mutation order in FLT3 mutant AML
This study is looking at how certain changes in the FLT3 gene affect the behavior of cancer cells in people with acute myeloid leukemia (AML), using special tools to better understand how these changes might influence the disease and its response to treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10906942 on NIH RePORTER |
What this research studies
This research investigates the role of FLT3 mutations in acute myeloid leukemia (AML) by examining how these mutations influence the behavior of cancer cells. Using advanced techniques like CRISPR and novel mouse models, the study aims to uncover the order of mutations and their dependency on specific oncogenes within leukemic cell populations. By analyzing these interactions, the research seeks to provide insights into the mechanisms driving AML progression and treatment resistance.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with acute myeloid leukemia, particularly those with FLT3 mutations.
Not a fit: Patients without FLT3 mutations or those with other types of leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with FLT3-mutant AML by targeting specific mutations and their interactions.
How similar studies have performed: Previous research has shown promising results in targeting FLT3 mutations in AML, indicating that this approach has potential for success.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Bowman, Robert Lyle — University of Pennsylvania
- Study coordinator: Bowman, Robert Lyle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.