Understanding How Flexible Proteins in Our Bodies Are Shaped
Structural characterization of large eukaryotic proteins containing both folded and disordered domains
This project aims to understand how flexible proteins in our bodies work, as their malfunction is linked to serious conditions like cancer and heart disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11193770 on NIH RePORTER |
What this research studies
Many important proteins in our bodies are very flexible, and their shape changes are crucial for how our cells function. When these flexible proteins don't work right, it can lead to diseases like cancer, diabetes, and heart problems. Traditionally, scientists have studied parts of these proteins separately, but this project will look at the whole protein to get a more complete picture. By understanding these proteins better, we hope to uncover new ways to address these serious health conditions.
Who could benefit from this research
Good fit: Patients with conditions like cancer, diabetes, cardiovascular disease, or neurodegenerative disorders may eventually benefit from the foundational knowledge gained from this research.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention will not receive direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this fundamental understanding of protein function could pave the way for new treatments for a range of diseases, including cancer and cardiovascular conditions.
How similar studies have performed: This project proposes a novel, holistic approach to studying complex proteins, moving beyond traditional methods that examine protein parts in isolation.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Wright, Peter Edwin — Scripps Research Institute, the
- Study coordinator: Wright, Peter Edwin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.