Understanding how flaviviruses infect cells
Official title: Elucidating the Proteolytic Determinants of Flavivirus Infection
Funded at University of Alabama at Birmingham · NIH-11082988 · Data updated 2026-11-12
This study is looking at how certain viruses, like Zika and dengue, get into and multiply inside our cells, with the hope of finding new ways to create treatments that could help patients affected by these diseases.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $44,292 |
| NIH project number | 5F31AI183737-02 |
| Project ID | NIH-11082988 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals at risk for flavivirus infections, such as those living in endemic areas or travelers to these regions.
✕Less likely to help
Patients who are not at risk for flavivirus infections or those with existing antiviral treatments may not receive direct benefits from this research.
What this research studies
This research investigates the mechanisms by which flaviviruses, a group of viruses that can cause diseases like Zika and dengue, enter and replicate within human cells. The study focuses on specific proteins involved in the viral lifecycle, particularly how they interact with cellular components to facilitate infection. By using advanced laboratory techniques, researchers aim to identify the molecular factors that influence the effectiveness of viral replication and how these factors can be targeted for therapeutic development. Patients may benefit from insights gained that could lead to new antiviral treatments.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antiviral therapies that effectively combat flavivirus infections.
How similar studies have gone: Previous research has shown promise in understanding viral mechanisms and developing antiviral strategies, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Corliss, Lochlain — University of Alabama at Birmingham
- Study coordinator: Corliss, Lochlain
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.