Understanding how flavivirus infections affect the brain
A clear view of encephalitis: a single cell approach to determine the basis of flaviviral pathogenesis in the central nervous system
This study is looking at how certain viruses that can cause serious brain inflammation affect different types of brain cells, using mice and human stem cells, to find new ways to treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11001549 on NIH RePORTER |
What this research studies
This research investigates how flavivirus infections, which can lead to severe brain inflammation, impact different cell types in the central nervous system. By using advanced imaging techniques and mouse models, the study aims to uncover the immune responses triggered by these viruses and how they interact with brain cells. The researchers will also utilize human stem cell models to gain insights into these processes. This approach could help identify potential targets for new treatments for encephalitis caused by flaviviruses.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have been diagnosed with encephalitis caused by flavivirus infections.
Not a fit: Patients with encephalitis caused by non-flavivirus pathogens may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies for patients suffering from flavivirus-induced encephalitis.
How similar studies have performed: Previous research has shown promise in understanding viral interactions with the central nervous system, but this specific approach using advanced imaging techniques is relatively novel.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Rice, Charles M — Rockefeller University
- Study coordinator: Rice, Charles M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.