Understanding how filarial parasites release substances that affect human health
Molecular mechanisms controlling secretion in filarial nematode parasites
This study is looking at how a type of parasite that causes lymphatic filariasis, which affects over 1.5 billion people, manages to survive in the human body by releasing substances that help it avoid the immune system, with the hope of finding new ways to treat infections caused by these parasites.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10763000 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that control how filarial nematode parasites, which infect over 1.5 billion people, secrete substances that help them survive in human hosts. By focusing on Brugia malayi, a parasite responsible for lymphatic filariasis, the project aims to uncover the biological processes that enable these parasites to modulate the host's immune response. The researchers will identify key regulators of the secretory functions of these parasites, which could lead to the development of new antiparasitic treatments. This work is crucial as current treatments are limited and face challenges such as drug resistance.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals infected with filarial nematodes, particularly those suffering from lymphatic filariasis.
Not a fit: Patients who are not infected with filarial nematodes or do not have related health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new and more effective treatments for parasitic infections, improving health outcomes for millions of affected individuals.
How similar studies have performed: Other research has shown promise in targeting the secretory mechanisms of parasites, indicating that this approach could yield significant advancements in treatment options.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Zamanian, Mostafa — University of Wisconsin-Madison
- Study coordinator: Zamanian, Mostafa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.