Understanding how fibrous tissue interfaces work
Multiscale models of fibrous interface mechanics
This study is looking at how different types of body tissues, like tendons and bones, connect to each other to find out why some surgeries don’t work as well as they should, with the goal of creating better ways to help people heal after surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10898594 on NIH RePORTER |
What this research studies
This research investigates the mechanics of fibrous interfaces between different types of tissues in the body, such as where tendons attach to bones. It aims to understand why some surgical repairs fail and how the structure of these interfaces can be improved. By developing models and conducting experiments, the researchers will explore the factors that contribute to the strength and toughness of these connections. This work could lead to better surgical techniques and materials that enhance healing and reduce complications.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients undergoing surgeries related to tendon and ligament repairs, particularly older adults with rotator cuff injuries.
Not a fit: Patients with conditions unrelated to fibrous tissue interfaces or those not requiring surgical intervention may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved surgical outcomes and reduced failure rates in procedures involving fibrous tissue repairs.
How similar studies have performed: Previous research has shown promise in understanding tissue interfaces, but this specific approach to modeling fibrous mechanics is relatively novel.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Genin, Guy M — Washington University
- Study coordinator: Genin, Guy M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.