Understanding how fibrosis affects aging stem cells using advanced materials
Elucidating Effects of Fibrosis on Aged Stem Cells with Dynamic Biomaterials
This study is looking at how scarring in muscles affects the ability of muscle stem cells to work as we get older, using special materials to mimic the conditions in our bodies, with the hope of finding new ways to help muscles heal and regenerate.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11017833 on NIH RePORTER |
What this research studies
This research investigates the impact of fibrosis on muscle stem cells (MuSCs) as they age, using innovative dynamic hydrogel materials to create a realistic model of the fibrotic environment. By adjusting the mechanical properties of these hydrogels, the study aims to explore how changes in the cellular microenvironment influence the behavior and regenerative capacity of MuSCs. The goal is to uncover the molecular mechanisms behind MuSC dysfunction in aging, which could lead to new insights into muscle regeneration and repair.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing muscle weakness or degeneration due to aging.
Not a fit: Patients with acute muscle injuries or those not affected by age-related muscle dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for age-related muscle degeneration and enhance regenerative medicine approaches.
How similar studies have performed: Previous research has shown promising results in using dynamic biomaterials to study cellular responses, indicating potential for success in this novel approach.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Madl, Christopher Matthew — University of Pennsylvania
- Study coordinator: Madl, Christopher Matthew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.