Understanding how fibroblasts in the meninges affect brain development and function
Official title: CNS Fibroblast Formation and Function
Funded at University of Colorado Denver · NIH-11094100 · Data updated 2026-11-12
This study is looking at special cells in the protective layers around the brain to see how they help the brain grow and work properly, especially before birth, and it hopes to find ways to prevent or treat brain development issues that some people face.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | June 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $382,271 |
| NIH project number | 5R01NS131823-02 |
| Project ID | NIH-11094100 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with congenital brain abnormalities or neurodevelopmental disorders.
✕Less likely to help
Patients with unrelated neurological conditions or those over the age of 21 may not receive direct benefits from this research.
What this research studies
This research investigates the role of specialized fibroblasts in the meninges, the protective layers surrounding the brain. It aims to understand how these cells contribute to brain development and function, particularly during fetal life. By studying the molecular mechanisms and signaling pathways involved, the research seeks to uncover how defects in these fibroblasts may lead to neurodevelopmental disorders. Patients may benefit from insights gained into the prevention and treatment of such conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for neurodevelopmental disorders linked to meningeal fibroblast defects.
How similar studies have gone: While the specific focus on meningeal fibroblasts is relatively novel, similar research has shown success in understanding the role of other cell types in brain development.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Siegenthaler, Julie — University of Colorado Denver
- Study coordinator: Siegenthaler, Julie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.