Understanding how fibroblasts affect heart problems in Duchenne muscular dystrophy
Paracrine actions of fibroblasts promote pathologic cardiac myocyte remodeling in Duchenne muscular dystrophy
['FUNDING_R01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-10890672
This study is looking at how certain cells in the heart, called fibroblasts, affect heart problems in people with Duchenne muscular dystrophy (DMD), and it aims to find ways to help improve heart health for those living with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-10890672 on ClinicalTrials.gov |
What this research studies
This research investigates the role of fibroblasts in the heart of patients with Duchenne muscular dystrophy (DMD), a condition that leads to muscle degeneration and can cause serious heart issues. The study aims to identify the specific mechanisms by which fibroblasts contribute to heart disease in DMD, particularly focusing on a hormone called FGF23 that may play a significant role in disease progression. By understanding these processes, the researchers hope to develop targeted therapies that can improve heart health in DMD patients. The approach includes studying genetic mouse models and analyzing the interactions between cardiac myocytes and fibroblasts.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Duchenne muscular dystrophy, particularly those experiencing cardiac complications.
Not a fit: Patients without Duchenne muscular dystrophy or those who do not have cardiac involvement may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve heart health and overall quality of life for patients with Duchenne muscular dystrophy.
How similar studies have performed: Other research has shown promising results in understanding cardiac complications in muscular dystrophies, suggesting that this approach could yield valuable insights.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WELC, STEVEN S — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: WELC, STEVEN S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cardiac Diseases, Cardiac Disorders, Cardiovascular Diseases