Understanding how fibrinogen is produced and processed in the liver
Official title: Novel Mechanism underlying fibrinogen biogenesis in the endoplasmic reticulum
Funded at University of Virginia · NIH-10874727 · Data updated 2026-11-12
This study is looking at how the body makes and controls a key protein called fibrinogen, which is important for blood clotting, especially for people with a liver condition called hepatic fibrinogen storage disease, to help find better treatments for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | December 15, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $401,244 |
| NIH project number | 5R01DK132068-04 |
| Project ID | NIH-10874727 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with hepatic fibrinogen storage disease or related coagulation disorders.
✕Less likely to help
Patients without any bleeding disorders or those not affected by fibrinogen-related conditions may not benefit from this research.
What this research studies
This research investigates the mechanisms behind the production and quality control of fibrinogen, a crucial protein for blood clotting, particularly in the context of hepatic fibrinogen storage disease (HFSD). The study focuses on how certain proteins in the endoplasmic reticulum (ER) manage the biogenesis of fibrinogen and how mutations can lead to liver damage and bleeding disorders. By using mouse models that mimic human conditions, the research aims to uncover the molecular events that regulate fibrinogen production and degradation, which could lead to new therapeutic strategies for patients affected by related diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with bleeding disorders caused by fibrinogen abnormalities.
How similar studies have gone: Previous research has shown success in understanding protein misfolding diseases, indicating that this approach may yield valuable insights.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Sun, Shengyi — University of Virginia
- Study coordinator: Sun, Shengyi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.