Understanding how fibrinogen and factor XIII affect blood clotting and bleeding
Official title: Using genomics and functional biology to understand fibrinogen and factor XIII and their effects on thrombotic diseases
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11049858 · Data updated 2026-11-12
This study is looking at how certain genetic differences in proteins that help your blood clot, called fibrinogen and factor XIII, might affect your risk of blood clots, with the goal of finding better ways to prevent and treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | February 1, 2025 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $745,002 |
| NIH project number | 2R01HL141291-05A1 |
| Project ID | NIH-11049858 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of thrombotic diseases or those of African ancestry who may be affected by specific genetic variations.
✕Less likely to help
Patients without any history of thrombotic diseases or those who do not have genetic predispositions related to fibrinogen and factor XIII may not benefit from this research.
What this research studies
This research investigates the roles of fibrinogen and factor XIII in blood coagulation, focusing on their genetic variations and how these variations influence thrombotic diseases. The study will analyze different forms of fibrinogen, particularly an alternatively spliced version with unique properties, and how they interact with factor XIII in the blood. By examining genetic determinants and their effects on clotting and bleeding, the research aims to provide insights that could lead to better prevention and treatment strategies for thrombotic conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of thrombotic diseases, potentially reducing the risk of complications for patients.
How similar studies have gone: Previous studies have shown promising results in understanding the genetic factors influencing blood coagulation, but this research aims to explore new aspects that have not been extensively studied.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Morrison, Alanna C — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Morrison, Alanna C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.