Understanding how Fgf8 affects jaw size and symmetry
Official title: Molecular and cellular mechanisms underlying Fgf8-dosage mediated defects in jaw size and symmetry
Funded at University of Massachusetts Lowell · NIH-10875804 · Data updated 2026-11-12
This study looks at how a signaling factor called Fgf8 affects jaw development, which could help us understand why some people have jaw-related birth defects, ultimately aiming to improve treatments for those conditions.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Massachusetts Lowell NIH-funded |
| Lab location | 1 site (Lowell, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $455,939 |
| NIH project number | 1R15DE033850-01 |
| Project ID | NIH-10875804 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with craniofacial malformations, particularly those associated with conditions like 22q11 deletion syndrome.
✕Less likely to help
Patients without craniofacial malformations or those not affected by related genetic syndromes may not benefit from this research.
What this research studies
This research investigates the molecular and cellular mechanisms that influence jaw development, particularly focusing on the role of the Fgf8 signaling factor. By examining how Fgf8 dosage impacts the growth and symmetry of the jaw skeleton, the study aims to uncover the underlying causes of craniofacial malformations. The approach involves analyzing the development of specific structures in the pharyngeal arches, which are crucial for proper jaw formation. Patients may benefit from insights gained into how these developmental processes can lead to birth defects.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential interventions for craniofacial malformations in affected patients.
How similar studies have gone: Previous research has shown promising results in understanding craniofacial development, indicating that this approach may yield valuable insights.
Where this research is happening
-
University of Massachusetts Lowell
Lowell, United States Active
Researchers
- Principal investigator: Fish, Jennifer Leslie — University of Massachusetts Lowell
- Study coordinator: Fish, Jennifer Leslie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.