Understanding how fetal development affects blood cell production in adults
Official title: Investigating the fetal origins of myeloid-biased hematopoietic stem cells
Funded at Stanford University · NIH-11039723 · Data updated 2026-11-12
This study is looking at how certain blood-making stem cells change as we get older, especially those that might be affected by our development before birth, to help us understand more about our immune system and blood-related issues in older adults.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | January 15, 2025 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $76,848 |
| NIH project number | 1R36AG090859-01 |
| Project ID | NIH-11039723 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals under 21 years old who may be affected by hematologic disorders or are interested in understanding the impacts of aging on blood cell production.
✕Less likely to help
Patients who are not within the age range of 21 years or older and do not have hematologic disorders may not benefit from this research.
What this research studies
This research investigates how hematopoietic stem cells (HSCs), which are crucial for blood cell production, change as we age. It focuses on a specific subset of HSCs that may be influenced by fetal development, particularly those marked by the Neogenin-1 surface marker. By using specialized mouse models, the research aims to uncover the origins and characteristics of these myeloid-biased HSCs, which could lead to better understanding of immune function and blood disorders in older adults.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for age-related blood disorders and enhanced immune function in older adults.
How similar studies have gone: While the specific focus on fetal origins of myeloid-biased HSCs is relatively novel, previous research has shown success in understanding HSC behavior and lineage output in relation to aging.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Banuelos, Allison — Stanford University
- Study coordinator: Banuelos, Allison
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.