Understanding how fear memories are formed and stored in the brain
The role of sex- and cell-type specific protein degradation increases in the amygdala in fear memory formation
This study is looking at how our brains create and store fear memories, especially in people with PTSD, and it wants to see if there are differences between men and women, so we can find better ways to help those who are struggling with these memories.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Polytechnic Inst and St Univ NIH-funded |
| Lab location | 1 site (Blacksburg, United States) |
| Project ID | NIH-11220791 on NIH RePORTER |
What this research studies
This research investigates the biological mechanisms behind fear memory formation, particularly focusing on the role of protein degradation in the amygdala, a key brain region for emotional processing. It aims to explore how these processes differ between males and females, especially in the context of post-traumatic stress disorder (PTSD). By examining the ubiquitin-proteasome system's involvement in fear memory, the study seeks to identify potential targets for improving treatments for PTSD. Patients may be asked to participate in assessments that help understand their fear responses and memory formation.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of trauma or PTSD, particularly those who identify as female.
Not a fit: Patients who do not have a history of trauma or PTSD may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for PTSD, particularly for those who are more susceptible based on sex.
How similar studies have performed: Previous research has shown promising results in understanding the role of protein degradation in memory formation, but this specific focus on sex differences in PTSD is relatively novel.
Where this research is happening
Blacksburg, United States
- Virginia Polytechnic Inst and St Univ — Blacksburg, United States (Active)
Researchers
- Principal investigator: Jarome, Timothy Joseph — Virginia Polytechnic Inst and St Univ
- Study coordinator: Jarome, Timothy Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.