Understanding how FBLL1 affects brain cell development
Official title: Elucidating the role of FBLL1 in ribosome function during neuronal differentiation
Funded at University of Connecticut Sch of Med/dnt · NIH-10996986 · Data updated 2026-11-12
This study is looking at a protein called FBLL1 to see how it helps brain cells, or neurons, grow and work properly, using special techniques to understand its role better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $45,419 |
| NIH project number | 1F31HD114435-01A1 |
| Project ID | NIH-10996986 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 21 and older who may have conditions related to neuronal differentiation or brain function.
✕Less likely to help
Patients with conditions unrelated to neuronal development or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the role of a protein called FBLL1 in the development of neurons, which are the cells in the brain. It focuses on how FBLL1 influences the modification of ribosomal RNA, a crucial component for protein synthesis in cells. By examining the expression of FBLL1 in neurons, the research aims to uncover its potential impact on neuronal differentiation and function. The study employs advanced techniques such as CRISPR to manipulate gene expression and analyze the resulting effects on brain cell development.
Why it matters
Potential benefit: If successful, this research could lead to new insights into brain development and potential therapies for neurological disorders.
How similar studies have gone: While the specific role of FBLL1 in neuronal differentiation is novel, similar studies on ribosomal RNA modifications have shown promising results in understanding brain development.
Where this research is happening
-
University of Connecticut Sch of Med/dnt
Farmington, United States Active
Researchers
- Principal investigator: Alshawi, Sarah Ann — University of Connecticut Sch of Med/dnt
- Study coordinator: Alshawi, Sarah Ann
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.