Understanding how fatty acids are processed in muscle diseases
Relevance of fatty acid handling in the adaptive response to mitochondrial dysfunction
This study looks at how the body handles fats when muscle cells aren't working as well as they should, and it aims to find ways to help people with mitochondrial myopathy by understanding how the liver and heart can support muscle energy production.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11043417 on NIH RePORTER |
What this research studies
This research investigates how fatty acids are managed in the body when there is a deficiency in mitochondrial function, particularly in skeletal muscle. It focuses on the relationship between fatty acid metabolism and the ability of muscles to produce energy through glucose and fatty acids. By examining how the liver and heart adapt to support muscle function, the study aims to uncover mechanisms that could help mitigate stress responses in muscle cells. Patients with mitochondrial myopathy may find this research relevant as it explores potential metabolic adaptations that could improve their condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with primary mitochondrial disease, particularly those experiencing mitochondrial myopathy.
Not a fit: Patients without mitochondrial dysfunction or those with unrelated metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing energy production in patients with mitochondrial diseases.
How similar studies have performed: Previous research has shown promising results in understanding metabolic adaptations in similar conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
Philadelphia, United States
- Thomas Jefferson University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Seifert, Erin — Thomas Jefferson University
- Study coordinator: Seifert, Erin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.