Understanding how fatty acid oxidation affects liver damage from acetaminophen
Official title: Fatty Acid Oxidation in Regulation of Drug Hepatotoxicity
Funded at VA Veterans Administration Hospital · NIH-10796173 · Data updated 2026-11-12
This study is looking at how the way your liver breaks down fats might affect recovery from liver damage caused by too much acetaminophen, and it’s for anyone interested in understanding how the liver heals after such an overdose.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Veterans Administration Hospital NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project start | January 1, 2019 |
| Project end | September 30, 2028 |
| Funding year | 2025 |
| NIH project number | 2I01BX003275-06 |
| Project ID | NIH-10796173 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced acetaminophen overdose or are at risk of acetaminophen-induced liver injury.
✕Less likely to help
Patients who have liver conditions unrelated to acetaminophen or those not at risk of drug-induced liver injury may not benefit from this research.
What this research studies
This research investigates the role of fatty acid oxidation in liver injury caused by acetaminophen overdose. It aims to understand the mechanisms behind acetaminophen-induced liver injury (AILI) and how the liver can regenerate after such damage. The study will explore how inhibiting or enhancing fatty acid oxidation affects liver recovery and injury, focusing on specific enzymes involved in this process. By using various models, the research seeks to clarify the cellular processes that govern liver health and recovery after drug-induced damage.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from liver injury due to acetaminophen overdose.
How similar studies have gone: Previous research has indicated that understanding metabolic pathways in liver injury can lead to significant advancements in treatment, suggesting potential success for this approach.
Where this research is happening
-
VA Veterans Administration Hospital
Richmond, United States Active
Researchers
- Principal investigator: Wang, Xiang-Yang Shawn — VA Veterans Administration Hospital
- Study coordinator: Wang, Xiang-Yang Shawn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.