Understanding how fatty acid metabolism is affected in males with Klinefelter Syndrome
Interrogating Fatty Acid Metabolism Impairment andClinical Correlates in Males with Klinefelter Syndrome
This study is looking at how men with Klinefelter Syndrome, a condition caused by an extra X chromosome, deal with issues like insulin resistance and other metabolic problems, even before they show typical symptoms, to better understand how a specific protein might help improve their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10854965 on NIH RePORTER |
What this research studies
This research investigates the metabolic challenges faced by males with Klinefelter Syndrome, a genetic condition caused by an extra X chromosome. It focuses on understanding how these individuals experience insulin resistance and other metabolic issues, even before the onset of typical symptoms like hypogonadism. The study aims to explore the role of a specific protein, PPAR-α, which is involved in regulating fatty acid metabolism and may provide insights into potential therapeutic interventions. By analyzing metabolic and genetic data, the research seeks to uncover the underlying mechanisms that contribute to these health challenges.
Who could benefit from this research
Good fit: Ideal candidates for this research are males diagnosed with Klinefelter Syndrome, particularly those experiencing metabolic issues.
Not a fit: Patients without Klinefelter Syndrome or those who do not exhibit metabolic challenges may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that improve metabolic health and overall quality of life for males with Klinefelter Syndrome.
How similar studies have performed: While research on Klinefelter Syndrome is ongoing, the specific focus on PPAR-α and its role in fatty acid metabolism is relatively novel and has not been extensively tested.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Davis, Shanlee — University of Colorado Denver
- Study coordinator: Davis, Shanlee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.