Understanding how fatty acid metabolism in peroxisomes affects aging and neurodegenerative diseases.
Peroxisomal fatty acid metabolism in genetic and age-related disorders
['FUNDING_OTHER'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-11117181
This study is looking at how tiny parts of our cells, called peroxisomes, help with breaking down fats and how problems with certain proteins can lead to issues like Alzheimer's disease, with the hope of finding new treatments for people dealing with age-related conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-11117181 on ClinicalTrials.gov |
What this research studies
This research investigates the role of peroxisomes, which are cellular organelles involved in fatty acid metabolism, in relation to genetic and age-related disorders. The study focuses on how defects in specific proteins, known as ABC transporters, can lead to metabolic disorders and contribute to conditions like Alzheimer's disease. By examining the structural details of these transporters and their function, the research aims to uncover how aging impacts fatty acid transport and metabolism. Patients may benefit from insights that could lead to new treatments for age-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic disorders affecting peroxisomal function, as well as those experiencing age-related neurodegenerative conditions.
Not a fit: Patients with metabolic disorders unrelated to peroxisomal function may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new therapeutic strategies for managing age-related neurodegenerative diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of peroxisomal metabolism in various disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GUPTA, MEGHNA — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: GUPTA, MEGHNA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Addison disease-cerebral sclerosis syndrome, Addison disease-spastic paraplegia syndrome, Addison-Schilder syndrome, adrenocortical atrophy-cerebral sclerosis syndrome