Understanding how fats move in cells to fight heart disease and inflammation
Phosphatidylinositol Metabolism and Trafficking in Atherosclerosis and Inflammation
This research explores how certain fats move within our cells, which could help us better understand and treat chronic inflammation and heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland State University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11131144 on NIH RePORTER |
What this research studies
Our bodies sometimes react poorly to modified fats and bacteria, leading to ongoing inflammation that contributes to serious conditions like atherosclerosis, a major cause of heart disease. This project looks closely at a specific protein called ATP8b1 and how it handles fats, particularly one called PIP2, within cells. By understanding this process, we hope to uncover new ways that cells manage inflammation and cholesterol. This knowledge could lead to new strategies for protecting your heart and reducing chronic inflammation.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals at risk for or living with atherosclerosis, cardiovascular disease, or chronic inflammatory conditions in the future.
Not a fit: Patients not affected by atherosclerosis, cardiovascular disease, or related inflammatory conditions may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat atherosclerosis and other inflammatory diseases by targeting how cells manage fats.
How similar studies have performed: While the connection between ATP8b1 and PIP2 trafficking is a novel area, other studies have shown the importance of lipid metabolism in inflammatory diseases.
Where this research is happening
Cleveland, United States
- Cleveland State University — Cleveland, United States (Active)
Researchers
- Principal investigator: Gulshan, Kailash — Cleveland State University
- Study coordinator: Gulshan, Kailash
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.