Understanding how fats move in cells to fight heart disease and inflammation
Official title: Phosphatidylinositol Metabolism and Trafficking in Atherosclerosis and Inflammation
Funded at Cleveland State University · NIH-11131144 · Data updated 2026-11-12
This research explores how certain fats move within our cells, which could help us better understand and treat chronic inflammation and heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland State University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | April 1, 2020 |
| Project end | June 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $540,777 |
| NIH project number | 5R01HL148158-07 |
| Project ID | NIH-11131144 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational research is not directly recruiting patients but aims to benefit individuals at risk for or living with atherosclerosis, cardiovascular disease, or chronic inflammatory conditions in the future.
✕Less likely to help
Patients not affected by atherosclerosis, cardiovascular disease, or related inflammatory conditions may not directly benefit from this specific research.
What this research studies
Our bodies sometimes react poorly to modified fats and bacteria, leading to ongoing inflammation that contributes to serious conditions like atherosclerosis, a major cause of heart disease. This project looks closely at a specific protein called ATP8b1 and how it handles fats, particularly one called PIP2, within cells. By understanding this process, we hope to uncover new ways that cells manage inflammation and cholesterol. This knowledge could lead to new strategies for protecting your heart and reducing chronic inflammation.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat atherosclerosis and other inflammatory diseases by targeting how cells manage fats.
How similar studies have gone: While the connection between ATP8b1 and PIP2 trafficking is a novel area, other studies have shown the importance of lipid metabolism in inflammatory diseases.
Where this research is happening
-
Cleveland State University
Cleveland, United States Active
Researchers
- Principal investigator: Gulshan, Kailash — Cleveland State University
- Study coordinator: Gulshan, Kailash
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.