Understanding how fats in cell nuclei affect diseases
Unexpected roles of phosphoinositides in the nucleus
This work explores how special fats inside the cell's control center, the nucleus, contribute to conditions like cancer and autoimmune diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-11136471 on NIH RePORTER |
What this research studies
Our bodies contain tiny fats called phosphoinositides (PIs) that are crucial for how our cells work, even though they are present in small amounts. When these PIs don't function correctly, it can lead to serious health problems such as cancer, autoimmune conditions, and nerve disorders. While PIs are known to be important for cell signaling, we are discovering that a significant portion of them are also found inside the cell's nucleus, where their exact roles are still a mystery. This project aims to uncover these unexpected functions of nuclear PIs and identify the proteins they interact with, which could reveal new ways diseases develop.
Who could benefit from this research
Good fit: This foundational research is not recruiting patients directly, but future clinical applications may benefit individuals with cancers, neurodegenerative diseases, metabolic disorders, or autoimmune conditions.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention would not find direct benefit from this basic science investigation.
Why it matters
Potential benefit: If successful, this research could lead to a deeper understanding of disease mechanisms and potentially identify new targets for treatments for conditions like cancer and autoimmune disorders.
How similar studies have performed: The roles of phosphoinositides in the cell nucleus are largely unknown, making this a novel and largely unexplored area of research.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Choi, Suyong — University of Nebraska Medical Center
- Study coordinator: Choi, Suyong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.