Understanding how fatigue affects decision-making and effort in daily activities
Official title: Behavioral and Neural Representations of Subjective Effort Cost
Funded at Hugo W. Moser Res Inst Kennedy Krieger · NIH-11310312 · Data updated 2026-11-12
This study is looking at how feeling tired affects the choices people with major depression make in their daily lives, helping us understand how fatigue influences their decisions and efforts in tasks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hugo W. Moser Res Inst Kennedy Krieger NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 1, 2019 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $641,268 |
| NIH project number | 5R01MH119086-06 |
| Project ID | NIH-11310312 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing significant fatigue, particularly those with major depressive disorders.
✕Less likely to help
Patients without symptoms of fatigue or those not diagnosed with neuropsychiatric conditions may not benefit from this research.
What this research studies
This research investigates the impact of fatigue on decision-making and effort in daily activities, particularly in individuals with major depressive disorders. By conducting experiments with human participants, the study aims to explore how fatigue evolves over time and influences choices related to effortful tasks. The researchers will utilize computational modeling and functional magnetic resonance imaging (fMRI) to analyze the relationship between subjective fatigue and decision-making processes. This comprehensive approach seeks to uncover the underlying mechanisms of fatigue and its effects on behavior.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for managing fatigue in patients with neuropsychiatric disorders.
How similar studies have gone: Previous research has shown promising results in understanding fatigue and decision-making, indicating that this approach has potential for significant insights.
Where this research is happening
-
Hugo W. Moser Res Inst Kennedy Krieger
Baltimore, United States Active
Researchers
- Principal investigator: Chib, Vikram S — Hugo W. Moser Res Inst Kennedy Krieger
- Study coordinator: Chib, Vikram S
Related research
Other NIH-funded projects on the same topics.
-
Understanding brain and movement in minimally speaking autistic people using wearable brain imaging
A new study will use comfortable wearable brain imaging to learn how the brains of minimally speaking autistic people control movement and speech-related skills.
-
Sleep and daily rhythms and brain development in autism
Aiming to understand how sleep problems and daily activity patterns affect brain growth, thinking skills, daily functioning, and autism symptoms in children.
-
Intellectual and Developmental Disabilities Research Center (IDDRC) at Kennedy Krieger/Johns Hopkins
A centers-based NIH grant supports researchers studying intellectual and developmental disabilities to find ways to prevent, diagnose earlier, and improve lives for people with conditions like autism and related disorders.
-
Microvascular brain blood flow and CSF cleaning in Lewy body dementia
A non-invasive MRI study in people with Alzheimer's-related dementias will explore how tiny blood vessel pulsations affect brain fluid clearance.
-
Improving how we spot late talking in bilingual kids
A project to help pediatric providers better identify true late talkers among Spanish-dominant bilingual toddlers so they can get timely help.
-
CEST imaging of muscle energy in heart failure patients
A heart-failure study tests a new MRI method to map how muscles use energy during exercise in adults with heart failure.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.