Understanding how fatigue affects decision-making and effort in daily activities

Behavioral and Neural Representations of Subjective Effort Cost

NIH-funded research Hugo W. Moser Res Inst Kennedy Krieger · NIH-11310312

This study is looking at how feeling tired affects the choices people with major depression make in their daily lives, helping us understand how fatigue influences their decisions and efforts in tasks.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionHugo W. Moser Res Inst Kennedy Krieger NIH-funded
Lab location1 site (Baltimore, United States)
Project IDNIH-11310312 on NIH RePORTER

What this research studies

This research investigates the impact of fatigue on decision-making and effort in daily activities, particularly in individuals with major depressive disorders. By conducting experiments with human participants, the study aims to explore how fatigue evolves over time and influences choices related to effortful tasks. The researchers will utilize computational modeling and functional magnetic resonance imaging (fMRI) to analyze the relationship between subjective fatigue and decision-making processes. This comprehensive approach seeks to uncover the underlying mechanisms of fatigue and its effects on behavior.

Who could benefit from this research

Good fit: Ideal candidates for this research include individuals experiencing significant fatigue, particularly those with major depressive disorders.

Not a fit: Patients without symptoms of fatigue or those not diagnosed with neuropsychiatric conditions may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for managing fatigue in patients with neuropsychiatric disorders.

How similar studies have performed: Previous research has shown promising results in understanding fatigue and decision-making, indicating that this approach has potential for significant insights.

Where this research is happening

Baltimore, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.