Understanding how fat tissue protein FGF21 affects aging and metabolism
Project2: Impact of adipose-tissue derived FGF21 on immunometabolic control of aging
This research explores how a protein from fat tissue, called FGF21, helps control metabolism and the immune system as we age.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11141103 on NIH RePORTER |
What this research studies
Our bodies' fat cells release many important substances, including a protein called FGF21, which seems to have a positive effect on our metabolism. We've developed a special mouse model where we can increase FGF21 specifically from fat cells. In these mice, higher levels of fat-derived FGF21 lead to better health and a longer life, suggesting that targeting fat tissue could be key to healthy aging. These mice also show improved metabolism and unique immune responses in their fat, which are different from typical aging changes.
Who could benefit from this research
Good fit: This foundational research is relevant for adults interested in the biological processes of aging and metabolic health.
Not a fit: Patients seeking immediate clinical treatments or direct participation in human trials would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new ways to improve metabolism, reduce age-related health problems, and potentially extend healthy lifespan in people.
How similar studies have performed: While FGF21 has been studied, this specific approach of manipulating fat-derived FGF21 to impact lifespan and health in aging is a novel finding from this research group.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Scherer, Philipp E — Yale University
- Study coordinator: Scherer, Philipp E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.