Understanding how fat tissue immune cells are affected by obesity
Cytokine and Metabolic Regulation of Adipose-tissue Tregs
This study is looking at how certain immune cells in fat tissue can help keep inflammation and metabolism in check, especially for people dealing with obesity, to find new ways to improve health and prevent issues like type-2 diabetes and heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10895290 on NIH RePORTER |
What this research studies
This research investigates the role of specific immune cells in fat tissue that help regulate inflammation and metabolic health, particularly in the context of obesity. It aims to uncover the mechanisms by which obesity reduces the effectiveness of these immune cells, known as regulatory T cells, and how this contributes to metabolic disorders like type-2 diabetes and cardiovascular diseases. The study employs advanced genetic and biochemical techniques to explore how factors such as cytokines and hormones influence these immune cells in both males and females. By understanding these processes, the research seeks to identify potential therapeutic targets for improving metabolic health in individuals affected by obesity.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults and children who are experiencing obesity-related metabolic disorders, such as insulin resistance or type-2 diabetes.
Not a fit: Patients who are not affected by obesity or related metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve metabolic health and reduce the risk of diseases associated with obesity.
How similar studies have performed: Previous research has shown promising results in understanding immune cell functions in obesity, indicating that this approach could yield valuable insights.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Li, Chaoran — Emory University
- Study coordinator: Li, Chaoran
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.