Understanding how fat tissue around blood vessels affects blood pressure regulation
Neurohumoral regulation of PVAT
This study is looking at how a type of fat around your blood vessels, called perivascular adipose tissue, affects blood pressure and heart health, especially for people dealing with conditions like high blood pressure and heart disease, to find new ways to help manage these issues.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-10980461 on NIH RePORTER |
What this research studies
This research investigates the role of perivascular adipose tissue (PVAT) in regulating blood pressure and vascular health. It aims to uncover how this fat tissue communicates with blood vessels and influences their function, particularly in the context of cardiovascular diseases like atherosclerosis and hypertension. By examining the mechanisms of neurotransmission in PVAT, the study seeks to identify how certain factors, including neurotransmitters, affect the activity of adipocytes in this tissue. The findings could provide insights into new therapeutic targets for managing blood pressure and cardiovascular health.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are at risk for or suffering from cardiovascular diseases.
Not a fit: Patients with cardiovascular diseases unrelated to blood pressure regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating cardiovascular diseases by targeting the mechanisms of blood pressure regulation.
How similar studies have performed: Previous research has shown promising results in understanding the role of adipose tissue in cardiovascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Gulbransen, Brian D. — Michigan State University
- Study coordinator: Gulbransen, Brian D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.