Understanding how fat tissue and lymphatic vessels interact
Regulation of Adipose-Lymphatic Cross-talk
This study is looking at how fat tissue and lymphatic vessels work together and affect each other, especially focusing on a substance called neurotensin that might play a role in fat metabolism, to help find new ways to manage weight and improve overall health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10834889 on NIH RePORTER |
What this research studies
This research investigates the complex relationship between adipose tissue and lymphatic vessels, focusing on how these two systems influence each other. It aims to uncover the molecular mechanisms behind the expression of neuropeptides, particularly neurotensin, in lymphatic endothelial cells and how these affect fat metabolism. By utilizing advanced techniques like single-cell RNA sequencing, the study will explore how changes in lymphatic function can lead to obesity and vice versa. The findings could provide new insights into how to regulate fat tissue and improve metabolic health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with obesity or metabolic disorders who may benefit from improved understanding and treatment of their conditions.
Not a fit: Patients who are not affected by obesity or metabolic disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for obesity and related metabolic disorders by targeting the interactions between fat tissue and lymphatic vessels.
How similar studies have performed: Other research has shown promising results in understanding the interactions between adipose tissue and lymphatic systems, suggesting that this approach could yield significant insights.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Rosen, Evan D — Beth Israel Deaconess Medical Center
- Study coordinator: Rosen, Evan D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.