Understanding how fat tissue affects metabolic health in people with HIV
Official title: Assessing the Interrelationship Between Adipose Tissue Thermogenesis and Fibrosis in the Metabolic Health of People Living with HIV
Funded at University of California, San Francisco · NIH-10993034 · Data updated 2026-11-12
This study is looking at how fat cells work in people with HIV and how this might affect their risk of diabetes, with the goal of finding ways to help improve their overall health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 10, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $700,000 |
| NIH project number | 1R01DK141041-01 |
| Project ID | NIH-10993034 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are experiencing metabolic health issues, such as insulin resistance or type 2 diabetes.
✕Less likely to help
Patients who are not living with HIV or those without metabolic health concerns may not benefit from this research.
What this research studies
This research investigates the relationship between fat tissue behavior and metabolic health in individuals living with HIV. It focuses on how certain types of fat cells, particularly those that help burn energy, may be suppressed in these individuals, leading to insulin resistance and type 2 diabetes. By examining the role of specific precursor cells that contribute to fat cell development, the study aims to uncover mechanisms that could improve metabolic health in this population. Patients may be involved in assessments that measure fat tissue characteristics and metabolic responses.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving metabolic health and reducing diabetes risk in people living with HIV.
How similar studies have gone: Previous research has shown promising results in understanding fat tissue dynamics and metabolic health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Koliwad, Suneil Krishna — University of California, San Francisco
- Study coordinator: Koliwad, Suneil Krishna
Related research
Other NIH-funded projects on the same topics.
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How fat tissue fuels insulin resistance in people living with HIV
This project looks at why people living with HIV have higher insulin resistance and diabetes risk, focusing on fat tissue, fibrosis, and the biology of fat cells.
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Understanding Fat Tissue Changes and Metabolic Health in People with HIV
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Myocardial fibrosis and fat in ART-treated women with HIV in sub-Saharan Africa
This project studies heart tissue changes in women with HIV in sub-Saharan Africa who are on antiretroviral therapy, to understand why they’re at higher risk for heart problems as they age.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.