Understanding how fat tissue affects energy balance and metabolism
Official title: Adipose FHL1 in energy homeostasis
Funded at Johns Hopkins University · NIH-10922811 · Data updated 2026-11-12
This study is looking at how a protein called FHL1 affects fat tissue and energy use in the body, which could help us understand insulin sensitivity better, and it includes insights from a 15-year-old with a unique genetic condition related to fat tissue.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 6, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $406,396 |
| NIH project number | 5R01DK136755-02 |
| Project ID | NIH-10922811 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adolescents with metabolic disorders or conditions affecting fat tissue development.
✕Less likely to help
Patients without metabolic disorders or those who do not have issues related to fat tissue development may not benefit from this research.
What this research studies
This research investigates the role of a specific protein, FHL1, in the development and function of fat tissue and its impact on overall energy metabolism and insulin sensitivity. By using cellular and animal models, researchers aim to understand how changes in this protein can affect the body's ability to manage energy and glucose levels. The study includes examining a unique case of a 15-year-old patient with a genetic deletion affecting fat tissue, which helps to inform the research on how similar mechanisms might work in the general population.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for metabolic disorders related to obesity and insulin resistance.
How similar studies have gone: Previous studies have shown success in understanding fat tissue biology and its implications for metabolism, suggesting that this research builds on established findings.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Anokye-Danso, Frederick — Johns Hopkins University
- Study coordinator: Anokye-Danso, Frederick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.