Understanding how fat signaling can help muscles heal and grow
Promoting Muscle Regeneration through Adipose Signaling
This study is looking at how a special type of fat in the body can help muscles heal and grow stronger, especially for people who have muscle weakness or disabilities, and it hopes to find new ways to support muscle recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10660957 on NIH RePORTER |
What this research studies
This research investigates the relationship between adipose tissue, specifically a type called intermuscular adipose tissue (IMAT), and muscle regeneration. It aims to understand how signals from fat can promote muscle growth and recovery, particularly in individuals suffering from muscle weakness and physical disabilities. By studying the mechanisms of how brown fat influences muscle cells, the researchers hope to find new therapeutic approaches to enhance muscle regeneration. The study utilizes a novel mouse model to explore these interactions and test potential treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing muscle weakness or physical disabilities, particularly those with conditions linked to the accumulation of intermuscular adipose tissue.
Not a fit: Patients without muscle weakness or those not affected by conditions related to adipose tissue accumulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve muscle strength and recovery for patients with muscle weakness.
How similar studies have performed: Other research has shown promising results in understanding fat-muscle interactions, suggesting that this approach could yield significant insights and advancements.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Meyer, Gretchen a — Washington University
- Study coordinator: Meyer, Gretchen a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.