Understanding how fat metabolism affects lung blood vessel disease
Official title: Lipidomics of Pulmonary Vascular Disease
Funded at Johns Hopkins University · NIH-11030920 · Data updated 2026-11-12
This study is looking at how certain fats in the body might affect people with pulmonary arterial hypertension (PAH), especially those with scleroderma, to see if these fats can help predict heart and lung health and possibly lead to new ways to manage or prevent the condition.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $122,813 |
| NIH project number | 1R03HL176624-01 |
| Project ID | NIH-11030920 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with scleroderma or those at risk for pulmonary arterial hypertension.
✕Less likely to help
Patients without any risk factors for pulmonary arterial hypertension or those not diagnosed with scleroderma may not benefit from this research.
What this research studies
This research investigates the role of long-chain fatty acids in pulmonary arterial hypertension (PAH), a serious condition affecting blood vessels in the lungs. By analyzing lipid metabolism in patients at risk for PAH, particularly those with scleroderma, the study aims to identify specific lipid signatures that correlate with heart and lung function. The researchers will validate their findings across different patient groups to see if these lipid profiles can predict clinical outcomes. This could lead to new dietary or medication strategies to manage or prevent PAH.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for patients at risk of pulmonary arterial hypertension.
How similar studies have gone: Previous research has shown promising results in understanding lipid metabolism in relation to pulmonary diseases, indicating potential for success in this approach.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Simpson, Catherine — Johns Hopkins University
- Study coordinator: Simpson, Catherine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.