Understanding how fat droplets are broken down in cells
Mechanisms of endosomal trafficking in lipid droplet catabolism
['FUNDING_OTHER'] · UNIVERSITY OF NEBRASKA MEDICAL CENTER · NIH-11077853
This study looks at how our cells break down fat storage to use for energy, especially when food is scarce, and it aims to find out how this process could help people with obesity and diabetes better manage their condition.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEBRASKA MEDICAL CENTER (nih funded) |
| Locations | 1 site (OMAHA, UNITED STATES) |
| Trial ID | NIH-11077853 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which lipid droplets, which store fats in cells, are broken down and utilized for energy. The study focuses on the role of specific proteins and lipids that influence the trafficking and degradation of these droplets, particularly during times of low nutrient availability. By examining how lipid droplets interact with cellular machinery, the research aims to uncover critical processes that could impact conditions like obesity and diabetes. Patients may benefit from insights gained into how fat metabolism can be regulated at the cellular level.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with obesity or metabolic disorders such as diabetes who are interested in understanding the underlying mechanisms of fat metabolism.
Not a fit: Patients who do not have metabolic disorders or obesity may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing obesity and diabetes by improving our understanding of fat metabolism.
How similar studies have performed: Other research has shown promising results in understanding lipid metabolism, but this specific approach to studying lipid droplet catabolism is relatively novel.
Where this research is happening
OMAHA, UNITED STATES
- UNIVERSITY OF NEBRASKA MEDICAL CENTER — OMAHA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHOTT, MICAH — UNIVERSITY OF NEBRASKA MEDICAL CENTER
- Study coordinator: SCHOTT, MICAH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.